At the Kahn lab we seek to understand how systems-level dynamics give rise to various aspects of brain function and behavior in health and disease.
To advance these goals, we take advantage of whole-brain functional imaging in humans and animal models. Functional magnetic resonance imaging (fMRI) is based on the blood oxygenation level-dependent (BOLD) signal which reflects the levels of regional oxygen supply, a known correlate of neural activity. Thus, fMRI allows us to measure activity in multiple brain systems simultaneously, and to look at dynamic interactions between regions of the brain. To manipulate well defined populations of neurons, we are using optogenetic techniques that enable cell-type specific optical control of electrical activity at a millisecond resolution. Combining optogenetic techniques with whole-brain fMRI (termed “opto-fMRI”), we study the mechanisms governing neural dynamics at the level of the microcircuit and across brain regions. Learn more about our research here.
The lab is located at the Ruth and Bruce Rappaport Faculty of Medicine and is affiliated with the Rappaport Institute and the Science and Engineering of Neural Systems group at the Technion – Israel Institute of Technology.