Ben Shofty, M.D.

ShoftyThe goal of my research program is to develop a platform that will enable to characterize the functional effects of the NF1 gene mutation on the central nervous system in the intact animal longitudinally over the days and months that these systems develop. Using cutting edge imaging technologies that allows for imaging of NF1 mice in the exact same way that we image our patients at the hospital (what we call a translational bridge), we have discovered a fundamental defect in a cerebral macro-circuit that we believe is responsible for the cognitive phenotype of NF1 patients. This finding represents a major breakthrough in translational neuroscience as it allows for the rapid development of targeted therapies for a group of neurological diseases, and conditional that we were not able to model and translate to humans before the development of our functional imaging methods.


2006-2008: B.Sc. in Medical Sciences, Tel Aviv University
2009-2012: M.D., Tel Aviv University


Shofty B., Constantini S., Freedman S., Ben-Sira l., and Kesler A. Optic pathway gliomas – current position and future directions. Harefua, 2010. 149(11): p. 721-5, 748.

Shofty B., Ben-Sira L.,Dvir R., Yalon M., Weintraub M., Constantini S., Freedman S., and Kesler A. Visual outcome following chemotherapy for progressive Optic Pathway Gliomas. Pediatric Blood Cancer, 2011. 57(3): p. 481-5.

Shofty B., Weizman L., Joskowicz L., Constantini S., Kesler A., Ben-Bashat D., Yalon M., Dvir R., Freedman S., Roth J., and Ben-Sira L. MRI Internal Segmentation of Optic Pathway Gliomas; Clinical Implementation of a Novel Algorithm. Child’s Nervous System, 2011. 27(8): p. 1265-72.

Weizman, L., Ben-Sira L., Joskowicz L., Constantini S., Precel R., Shofty B., Ben-Bashat D. Automatic segmentation, internal classification, and follow-up of optic pathway gliomas in MRI. Medical Image Analysis, 2012. 16(1): p. 177-88.

Shofty B., Ben-Sira L., Constantini S., Freedman S., Kesler A. Optic Nerve Sheath Diameter on MRI: Establishment of Norms and Comparison of Pediatric IIH Patients to Normal Controls. AJNR, American Journal of Neuroradiology, 2012. 33(2): p. 366-9.

Shofty B., Roth J., Ben-Sira L., Brotchi J., Korn A., and Constantini S. Massive hematomyelia following intramedullary spinal cord tumor surgery. Acta Neurochirurgica (Wien), 2012. 154(4): p. 751-2.

L. Weizman, L. Ben-Sira, L. Joskowicz, O. Aizenstein, B. Shofty, S. Constantini and D. Ben-Bashat. Prediction of brain MR scans in longitudinal tumor follow-up studies, N. Ayache, H. Delingette, P. Golland and K. Mori (Eds.): MICCAI 2012, Part I, Springer LNCS 7511, pp.179-187, 2012.

Weizman L., Helfer D., Ben Bashat D., Pratt L., Joskowicz L., Constantini S., Shofty B., and Ben Sira L.. PNist: Interactive Volumetric Measurements of Plexiform Neurofibromas in MRI Scans. International Journal of Computer Assisted Radiology and Surgery, 9(4): p. 683-93, 2014.

Shofty B., Constantini S., Bokstein F., Ram Z., Ben-Sira L., Freedman S., Vainer G., and Kesler A. Optic Pathway Gliomas in Adults. Neurosurgery, 2014. 74(3): p. 273-9; discussion 279-80.19.

Weizman L., Ben Sira L., Joskowicz L., Rubin D.L., Yeom K.W., Constantini S., Shofty B., and Ben Bashat D. Semiautomatic segmentation and follow-up of multicomponent low-grade tumors in longitudinal brain MRI studies. Medical Physics, 2014. 41(5): p. 052303.

Ram S.T., Neuberger A., Thapa L.J., Vir Singh R.P., Shofty B., and Schwartz E. Japanese Encephalitis among Patients with Acute Encephalitic Syndrome Admitted to a Tertiary Hospital in Chitwan, Nepal – A Prospective Observational Study. PLoS One, 2014. 9(6): p. e99999.

Pratt L., Helfer D., Weizman L., Shofty B., Constantini S., Joskowicz L., Ben Bashat D., and Ben-Sira L. Tumor burden evaluation in NF1 patients with plexiform neurofibromas in the daily clinical practice. Acta Neurochirurgica (Wien), 2015 May;157(5):855-61.

Shofty B., Mauda-Havakuk M., Weizman L., Constantini S., Ben-Bashat D., Dvir R., Pratt L., Joskowicz L., Kesler A., Yalon M., Ravid L., and Ben-Sira L. The effect of chemotherapy on optic pathway gliomas and their sub-components; a volumetric MR analysis study. Pediatric Blood Cancer, 2015 Aug;62(8):1353-9.

Shofty B., Grossman R. Treatment Options for Chronic Subdural Hematoma. World Neurosurgery, March 2016, 87:529-30.

Shofty B., Neuberger A., Naffaa ME., Binawi T., Babitch T., Rappaport ZH., Zaaroor M., Sviri G., and Paul M. Intrathecal or intraventricular therapy for post-neurosurgical Gram-negative meningitis: matched cohort study. Clinical Microbiology and Infection, 2016 Jan;22(1):66-70.

Shofty B, Constantini S., and Ben-Shachar S. Advances in Molecular Diagnosis of Neurofibromatosis Type 1. Semin Pediatr Neurol, 2015 Dec;22(4):234-9.

Neuberger, A. Shofty, B. Yahav, D. Naffaa, M. Bishop, B. Binawy, T. Babitch, T. Rappaport, Z. Zaaroor, M. Sviri, G. and Paul, M. Risk factors associated with death or neurological deterioration among patients with Gram-negative postneurosurgical meningitis Clinical Microbiology and Infection. 2016 Jun;22(6):573.e1-4.

Shimony N, Shofty B, Ram Z, Grossman R. Perioperative risk assessment of patients with gliomatosis cerebri. World Neurosurgery. 2016 Nov 8. pii: S1878-8750(16)31158-5.

Shimony N, Shofty B, Harosh CB, Sitt R, Ram Z, Grossman R. Surgical Resection of Cerebral Metastases Leads to Faster Resolution of Peritumoral Edema than Stereotactic Radiosurgery: A Volumetric Analysis. Annals of Surgical Oncology, 2016 Nov 28.

Shimony N, Gonen L, Shofty B, Abergel A, Fliss DM, Margalit N. Surgical resection of skull-base chordomas: experience in case selection for surgical approach according to anatomical compartments and review of the literature. Acta Neurochir (Wien). 2016 Dec 6.

Chapters in Edited Volumes

Shofty B., Ben-Sira L, Kesler A., and Constantini S. Optic Pathway Gliomas. Advance and technical standards in Neurosurgery,. Edited by Schramm, J., Akalan, N., Benes, V., Di Rocco, C., Dolenc, V.V., Lobo Antunes, J., Pickard, J.D., Rappaport, Z.H., Sindou, M.; Springer publishing group, 2015;42:123-46. 2013.

Shofty B., Ben-Sira L, Kesler A., and Constantini S. Optic Pathway Gliomas. Principles and Practice of Pediatric Neurosurgery, 3rd edition. Edited by Albright, Pollack and Adelson; Thieme publishing group. 2012.

Ben Shofty, Akiva Korn, Zvi Lidar, and Shlomi Constantini. Intradural Spinal Cord Tumors. Neurology in practice; Neuro-Oncology, 1st edition, edited by Roger Packer and David Schiff. John Wiley and sons, 2012.